6-Methoxy-7-Hydroxyquinazolin-4-One CAS 162012-72-8 Gefitinib Intermediate Purity >98.0% (HPLC)

Short Description:

6-Methoxy-7-Hydroxyquinazolin-4-One

CAS: 162012-72-8

Purity: >98.0% (HPLC)

Appearance: White to Off-White Solid

Intermediate of Gefitinib (CAS: 184475-35-2)

Contact: Dr. Alvin Huang

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E-Mail: alvin@ruifuchem.com

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162012-72-8 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 6-Methoxy-7-Hydroxyquinazolin-4-One (CAS: 162012-72-8) with high quality, intermediate of Gefitinib (CAS: 184475-35-2). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Gefitinib Intermediates, Please contact: alvin@ruifuchem.com

Gefitinib Intermediates:

Gefitinib	CAS 184475-35-2
3-Chloro-4-Fluoroaniline	CAS 367-21-5
4-(3-Chloropropyl)morpholine	CAS 7357-67-7
4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol	CAS 184475-71-6
7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-One	CAS 199327-61-2
6-Methoxy-7-Hydroxyquinazolin-4-One	CAS 162012-72-8

162012-72-8 - Chemical Properties:

Chemical Name	6-Methoxy-7-Hydroxyquinazolin-4-One
Synonyms	7-Hydroxy-6-Methoxyquinazolin-4(1H)-One; 7-Hydroxy-6-Methoxy-3,4-Dihydroquinazolin-4-One; 7-Hydroxy-6-Methoxy-3H-Quinazolin-4-One; 7-Hydroxy-6-Methoxy-4(3H)-Quinazolinone; Gefitinib Intermediate 3
Stock Status	In Stock, Commercial Production
CAS Number	162012-72-8
Molecular Formula	C9H8N2O3
Molecular Weight	192.17 g/mol
Melting Point	>255℃(dec.)
Density	1.47±0.10 g/cm3
COA & MSDS	Available
Place of Origin	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

162012-72-8 - Specifications:

Items	Specifications	Results
Appearance	White to Off-White Solid	White Solid
Purity / Analysis Method	>98.0% (HPLC Area)	98.63%
1H NMR Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested and complies with the given specifications

162012-72-8 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

162012-72-8 - Application:

6-Methoxy-7-Hydroxyquinazolin-4-One (CAS: 162012-72-8), intermediate of Gefitinib (CAS: 184475-35-2). Gefitinib is an antineoplastic target therapy drug with relatively high specificity that was developed by the British pharmaceutical company AstraZeneca; it is the first molecular targeted drug to be used in non-small cell lung cancer treatment. Epidermal growth factors (EGF) are a kind of polypeptide with a relative molecular mass of 6.45x103, and they can bind with epidermal growth factor receptors (EGFR) on target cell membrane surfaces to trigger biological effects. EGFR is a type of tyrosine kinase (TK) type receptor, so when bound with EGF, it will promote TK activation in the receptor. This will cause tyrosine residue in the receptor to autophosphorylate and send continuous dividing signals into the cell, causing cell proliferation and differentiation. EGFR is abundant in human tissue, and it is highly expressed in malign tumors. Gefitinib blocks the signal transduction pathway of cell surface EGFR to prevent tumor growth, metastasis, and growth in blood vessels, and it can induce tumor cell apoptosis. Gefitinib is mainly used to treat non-stem cell lung cancer.