Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu
Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – RuifuDetail:
Manufacturer with High Purity and Stable Quality
Chemical Name: Gemcitabine Hydrochloride
CAS: 122111-03-9
An Anticancer Agent
API USP Standard, High Quality, Commercial Production
| Chemical Name | Gemcitabine Hydrochloride |
| Synonyms | Gemcitabine HCl; 2′-Deoxy-2′,2′-difluorocytidine; dFdC |
| CAS Number | 122111-03-9 |
| CAT Number | RF-API41 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C9H12ClF2N3O4 |
| Molecular Weight | 299.66 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White Crystal Powder, Odorless |
| Solubility | Soluble in Water, slightly soluble in methanol, practically insoluble in acetone |
| Identifiaction IR | IR spectrum should be concordant to that of the reference standard |
| Identifiaction Chloride | Positive. It meets the requirements of the tests for chloride |
| Appearance of Solution | Solution S in clear and not more intensely colored than reference solution BY7 |
| pH | 2.0~3.0 |
| Specific Rotation | +43.0° ~ +50.0° |
| Heavy Metals (Pb) | ≤10ppm |
| Loss on Drying | ≤1.0% |
| Residue on Ignition | ≤0.10% |
| Related Substances | |
| Cytosine | ≤0.10% |
| α-Isomer | ≤0.10% |
| Any Other Impurity | ≤0.10% |
| Total Impurities | ≤0.20% |
| Methanol | ≤0.30% |
| Toluene | ≤0.01% |
| Dichloromethane | ≤0.01% |
| Acetone | ≤0.50% |
| Assay | 98.0%~102.0% (Calculated on dried base) |
| Test Standard | United States Pharmacopeia (USP) Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Gemcitabine Hydrochloride (CAS: 122111-03-9) with high quality API.
Gemcitabine Hydrochloride (CAS: 122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.
Gemcitabine Hydrochloride (CAS: 122111-03-9) is a synthetic novel difluoro nucleoside drug that is anti-metabolic and antineoplastic. It is researched and developed by the Eli Lilly and Company and approved to be listed in South Africa, Sweden, the Netherlands, Australia and other countries in 1995. The United States Food and Drug Administration ( referred FDA) approved it as the first-line therapy for the clinical treatment of non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, as a pro-drug, is a good substrate for the acidification of deoxygenation of thymine kinase phosphorus in the cell, and under the action of the enzyme, it can be converted into the following metabolites: gemcitabine mono-phosphate (dFdCMP), gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP), among which the latter two are the active products.
Product detail pictures:
Related Product Guide:
We not only will try our greatest to offer superb companies to just about every buyer, but also are ready to receive any suggestion offered by our shoppers forSpecial Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu, The product will supply to all over the world, such as: Oman, Belgium, Madagascar, Our Company policy is "quality first, to be better and stronger, sustainable development" . Our pursuit goals is "for society, customers, employees, partners and enterprises to seek reasonable benefit". We aspirate to do cooperate with all different the auto parts manufacturers, repair shop, auto peer , then create a beautiful future! Thank you for taking time to browse our website and we would welcome any suggestions you may have that can help us to improve our site.
