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One of Hottest for 4-Bromo-DL-Mandelic Acid - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu Featured Image
  • One of Hottest for 4-Bromo-DL-Mandelic Acid - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu

One of Hottest for 4-Bromo-DL-Mandelic Acid - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu

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Our commission is to serve our users and clients with best quality and competitive portable digital products for Ezetimibe CAS 163222-33-1 Intermediate, Folic acid impurity A, CAS 83150-76-9, We take quality as the foundation of our success. Thus, we focus on the manufacture of the best quality products. A strict quality management system has been created to ensure the quality of the products.
One of Hottest for 4-Bromo-DL-Mandelic Acid - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu Detail:

Commercial Supply Bedaquiline Related Intermediates:
3-Benzyl-6-Bbromo-2-Mmethoxyquinoline CAS: 654655-69-3
3-Benzyl-6-Bromo-2-Chloroquinoline CAS: 654655-68-2
3-(Dimethylamino)-1-(Naphthalen-1-yl)propan-1-one Hydrochloride CAS: 5409-58-5
Bedaquiline CAS: 843663-66-1
Bedaquiline Fumarate CAS: 845533-86-0

Chemical Name 3-Benzyl-6-Bromo-2-Chloroquinoline
Synonyms 6-Bromo-2-Chloro-3-(Phenylmethyl)quinoline; Bedaquiline Impurity B; Bedaquiline Fumarate Impurity 5
CAS Number 654655-68-2 
CAT Number RF-PI107
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C₁₆H₁₁BrClN
Molecular Weight 332.62
Brand Ruifu Chemical
Item Specifications
Appearance White to Off-White or Light Yellow Powder
Purity / Analysis Method ≥99.0% (HPLC)
Melting Point 100.0~120.0℃
Moisture (K.F) ≤0.50%
Residue on ignition ≤0.50%
Test Standard Enterprise Standard
Usage Bedaquiline Fumarate (CAS: 845533-86-0) Intermediate

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10
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3-Benzyl-6-bromo-2-chloroquinoline CAS: 654655-68-2 is a main intermediate of Bedaquiline.
Bedaquiline Fumarate is a diarylquinone drug developed by Janssen Pharmaceutical. The drug, which was approved in 2012 for the treatment of multidrug-resistant tuberculosis (MDR-TB), was developed in partnership with Johnson & Johnson and represents the first new tuberculosis therapy approved in over four decades. Bedaquiline is the first member of a new class of diarylquinone compounds whose mechanism of action inhibits Mycobaterium tuberculosis ATP synthase which deprives bacterium of energy.
Bedaquiline Fumarate used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of th mycobacteria.

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