New Delivery for Pregabalin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu

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Bear "Customer initially, High-quality first" in mind, we work closely with our prospects and supply them with efficient and specialist companies for Weight 320.75, (R)-(-)-α-Methoxyphenylacetic Acid, Weight 277.17, We are highly aware of quality, and have the certification ISO/TS16949:2009. We are dedicated to supply you high quality products with reasonable price.

New Delivery for Pregabalin - Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity – Ruifu Detail:

Manufacturer Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name	Irinotecan Hydrochloride
Synonyms	Camptothecin II; CPT-II
CAS Number	100286-90-6
CAT Number	RF-API50
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C33H39ClN4O6
Molecular Weight	623.15
Melting Point	250-256℃ (dec.)
Storage Conditions	Under Ambient Temperature
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Off-White Powder
Solubility	Soluble in water and methanol, slightly soluble in chloroform, ethanol
Identification IR	The infrared absorption spectrum of the test sample should consistent with that of the reference standard
Identification HPLC	The retention time of major peak of the sample solution should correspond to that of the reference standard.
Identification	Meets the requirements of the tests for Chloride Positive reaction
Moisture (K.F)	7.0%~9.0% w/w
Residue on Ignition	≤0.10%
Heavy Metals	≤20ppm
Irinotecan Hydrochloride Enantiomer	≤0.10% (HPLC)
7-Desethyl Irinotecan	≤0.15%
Irinotecan Related Compound A	≤0.15%
11-Ethyl Irinotecan	≤0.15%
Camptothecin	≤0.15%
Irinotecan Related Compound B	≤0.15%
7-Ethylcanptothecin	≤0.15%
7,11-Diethyl-10-Hydroxy Camptothecin	≤0.15%
Any Unspecified Impurity	≤0.10%
Total Impurities	≤0.50%
Residual Solvents (GC)
Methanol	≤2000ppm
Acetone	≤2000ppm
Dichloromethane	≤500ppm
Peteoleum Ether:	≤100ppm
Ethyl Acetate	≤2000ppm
Benzene	≤2ppm
Bacterial Endotoxins	≤0.29 EU/mg Irinotecan
Microbial Limits	Total Aerobic Microbial Count: <1000 cfu/g
Molds and Yeasts	<100 cfu/g
Purity / Analysis Method	≥99.0% (HPLC, on the anhydrous basis)
Test Standard	United States Pharmacopeia (USP) Standard
Usage	Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

lrinotecan hydrochloride (CAS 100286-90-6), a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin’s lymphoma.

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