Hot Sale for Uridine 5-Monophosphate Disodium Salt Hydrate - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – Ruifu
Hot Sale for Uridine 5-Monophosphate Disodium Salt Hydrate - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – RuifuDetail:
Manufacturer with High Quality and Competitive Price
Commercial Supply Solifenacin Succinate (CAS: 242478-38-2) Related Intermediates:
Solifenacin Succinate CAS: 242478-38-2
(R)-(-)-3-Quinuclidinol CAS: 25333-42-0
(S)-(+)-3-Quinuclidinol CAS: 34583-34-1
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
(R)-3-Quinuclidinol Hydrochloride CAS: 42437-96-7
1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline CAS: 22990-19-8
(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS: 118864-75-8
| Chemical Name | (S)-(+)-3-Quinuclidinol |
| Synonyms | (S)-Quinuclidin-3-ol; Solifenacin Succinate Intermediate B |
| CAS Number | 34583-34-1 |
| CAT Number | RF-CC118 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C7H13NO |
| Molecular Weight | 127.18 |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Off-White to White Crystalline Powder |
| Identification IR Specturm | Conforms to Reference Spectrum |
| Specific Rotation [α]D20 | 44.0°±2.0° |
| Loss On Drying | ≤0.50% |
| Purity | ≥99.0% |
| Assay | 98.0%~102.0% (on anhydrous basis) |
| Test Standard | Enterprise Standard |
| Usage | Chiral Compounds; Pharmaceutical Intermediates |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-(+)-3-Quinuclidinol (CAS: 34583-34-1) with high quality, widely used in synthesis of pharmaceutical intermediates and active pharmaceutical ingredient (API). (S)-(+)-3-Quinuclidinol is an intermediate in the synthesis of Solifenacin Succinate (CAS: 242478-38-2).
Solifenacin Succinate (CAS: 242478-38-2) is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or incontinence. Solifenacin Succinate is an M3 muscarinic receptor antagonist that was developed and launched for the treatment of overactive bladder (pollakiuria) in Europe. M3 receptors have been implicated in neurally evoked smooth muscle contractions of the bladder, and M2 receptors have also been suspected of playing a role because of their dominance in the detrusor muscle. Solifenacin displays affinity for both M3 and M2 receptors with Ki values of 9.9nM and 120 nM, respectively. Since muscarinic salivary glands are of the M3 persuasion, a common side effect of antimuscarinic therapy is dry mouth. At the cellular level, solifenacin possesses a selective preference for bladder over salivary gland that is 15-fold greater than that of atropine suggesting a lower probability of inducing dry mouth at pharmacologically relevant doses. The synthesis of solifenacin involves the preparation of racemic 1-phenyl- 1,2,3,4-tetrahydroisoquinoline via cyclization of N-(2-phenylethyl)benzamide, and subsequent reaction with ethyl chloroformate and transesterification with (R)- 3-quinuclidinol. Chiral chromatography affords the isolation of the desired diastereomer. Alternatively, 1-phenyl-1,2,3,4-tetrahydroisoquinoline may be subjected to optical resolution with (+)-tartaric acid prior to treatment with ethyl chloroformate and subsequent transesterification.
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"Quality 1st, Honesty as base, Sincere company and mutual profit" is our idea, in an effort to create consistently and pursue the excellence forHot Sale for Uridine 5-Monophosphate Disodium Salt Hydrate - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – Ruifu, The product will supply to all over the world, such as: Accra, Macedonia, Zimbabwe, We also have the strong ability of integration to supply our best service, and plan to build the warehouse in the different countries around the world, that will probably be more conveniently to service our customers.
