factory customized Tribenzoate - 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate – Ruifu

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factory customized Tribenzoate - 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate – Ruifu Detail:

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Chemical Name: 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
CAS: 160129-45-3

Chemical Name	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Synonyms	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one; 7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
CAS Number	160129-45-3
CAT Number	RF-PI395
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C10H10ClNO
Molecular Weight	195.65
Melting Point	103.0 to 107.0℃
Solubility	Soluble in Methanol
Brand	Ruifu Chemical

Item	Specifications
Appearance	Light Green to Light Yellow Powder
Identification Methods	NMR, HPLC
Purity / Analysis Method	≥99.0% (HPLC)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.50%
Any Single Impurity	≤0.50%
Total Impurities	≤1.0%
Test Standard	Enterprise Standard
Usage	Intermediate of Tolvaptan (CAS 150683-30-0), treatment of Hyponatremia

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) is an intermediate in the synthesis of Tolvaptan (CAS 150683-30-0). Tolvaptan is a selective, competitive orally active nonpeptide arginine vasopressin V2 receptor antagonist with an IC50 of 1.28µM for the inhibition of AVP-induced platelet aggregation. Tolvaptan is used to treat hyponatremia associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone. Tolvaptan is also in fast-track clinical trials for polycystic kidney disease. Treatment with Tolvaptan causes rapid and sustained body weight reductions concurrent with increases in urine output, improves and/or normalizes serum sodium in hyponatremic patients, reduces signs and symptoms of congestion and increases thirst.

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