2021 New Style (S)-(+)-4-Phenyl-2-oxazolidinone - 7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3 Irinotecan Hydrochloride Intermediate High Purity – Ruifu

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2021 New Style (S)-(+)-4-Phenyl-2-oxazolidinone - 7-Ethyl-10-Hydroxycamptothecin CAS 86639-52-3 Irinotecan Hydrochloride Intermediate High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4

Chemical Name	7-Ethyl-10-Hydroxycamptothecin
Synonyms	SN-38
CAS Number	86639-52-3
CAT Number	RF-PI242
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C22H20N2O5
Molecular Weight	392.41
Brand	Ruifu Chemical

Item	Specifications
Appearance	Light Yellowish White Crystals Powder
Identification (IR, UV)	(1) Ultraviolet ray absorption spectrum accord with the demands (2) Infrared ray absorption spectrum concordant with reference standard spectrum shall comply with approved tests
Melting Point	228.0~235.0℃
Related Substances	≤1.5%
10-Hydroxycamptothecin	≤0.30%
7-Cthylcamptothecin	≤0.70%
Maximum Unknown Impurity	≤0.50%
Loss on Drying	≤1.0%
Heavy Metals	≤10ppm
Residue on Ignition	≤0.10%
Clarity of Solution	Clear
Assay	≥98.0% (HPLC)
Test Standard	Enterprise Standard
Usage	Pharmaceutical Intermediate of Irinotecan

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) with high quality. 7-Ethyl-10-Hydroxycamptothecin (CAS: 86639-52-3) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. 7-Ethyl-10-Hydroxycamptothecin (SN-38), is the active metabolite of Irinotecan, a semisynthetic derivative of camptothecin, a quinoline-based alkaloid found in the bark of the Chinese camptotheca tree and the Asian nothapodytes tree. Although 7-Ethyl-10-Hydroxycamptothecin is up to 1,000 times more potent than Irinotecan, it has not been converted into a viable drug candidate because it is insoluble. It is presently being subjected to clinical trials in combination with other moieties which may ultimately allow it to be efficacious as an antineoplastic drug.

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