Valdecoxib CAS 181695-72-7 Purity >99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Valdecoxib (CAS: 181695-72-7) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in this product, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com
| Chemical Name | Valdecoxib |
| Synonyms | Bextra; SC 65872; Valus; Valz; 4-(5-Methyl-3-Phenyl-4-Isooxazolyl)benzenesulfonamide; 4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-yl)benzenesulfonamide; 4-(5-Methyl-3-Phenylisoxazol-4-yl)benzenesulfonamide |
| CAS Number | 181695-72-7 |
| CAT Number | RF2833 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C16H14N2O3S |
| Molecular Weight | 314.36 |
| Melting Point | 162.0~167.0℃ |
| Boiling Point | 481.2±55.0℃ |
| Density | 1.303±0.06 g/cm3 |
| Sensitive | Heat Sensitive |
| Water Solubility | Insoluble in Water |
| Solubility | Soluble in Ethanol, Methanol |
| Storage Temp. | Room Temperature |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White or Off-White Powder |
| Purity / Analysis Method | >99.5% (HPLC) |
| Melting Point | 162.0~167.0℃ |
| Water (by Karl Fischer) | <0.50% |
| Residue on Ignition | <0.20% |
| Single Impurity | <0.30% |
| Total Impurities | <0.50% |
| Heavy Metals (as Pb) | <20ppm |
| Infrared Spectrum | Conforms to Structure |
| NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | API, A Second-Generation COX-2 Inhibitor |
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
How to Purchase? Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Valdecoxib (CAS: 181695-72-7) is a second-generation COX-2 inhibitor, developed as a follow-up to celecoxib for the oral once-daily treatment of osteoarthritis, adult rheumatoid arthritis and menstrual pain. Valdecoxib is approximately 28,000-fold more selective against human recombinant COX-2 than human recombinant COX-1. In an ex viva human whole blood assay, the I&O values against COX-2 and COX-1 were respectively 0.89 PM and 25.4 FM. In animal models, valdecoxib possesses excellent oral activity as an antiinflammatory. In rats, valdecoxib potently inhibited carrageenan footpad edema and adjuvant-induced arthritis. Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in animal models. It is a potent and selective inhibitor of prostaglandin synthesis primarily through inhibition of COX-2. Valdecoxib is used to relieve some symptoms caused by arthritis (rheumatism), such as inflammation, swelling, stiffness, and joint pain. Valdecoxib is approved for the relief of the signs and symptoms of osteoarthritis and adult rheumatoid arthritis and for the treatment of primary dysmenorrhea. Valdecoxib is contraindicated for the treatment of postoperative pain immediately following coronary artery bypass graft surgery.
