Telmisartan CAS 144701-48-4 Purity >99.5% (HPLC) API Factory

Short Description:

Chemical Name: Telmisartan 

CAS: 144701-48-4

Purity: >99.5% (HPLC) 

Appearance: White or Off-White Crystalline 

Angiotensin II Receptor Antagonist

High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com


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Description:

Chemical Properties:

Chemical Name Telmisartan
Synonyms 4'-[[4-Methyl-6-(1-Methyl-1H-Benzimidazol-2-yl)-2-Propyl-1H-Benzimidazol-1-yl]methyl]biphenyl-2-Carboxylic Acid; 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-Benzimidazol]-1'-yl)methyl]-[1,1'-Biphenyl]-2-Carboxylic Acid
CAS Number 144701-48-4
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C33H30N4O2
Molecular Weight 514.63 
Melting Point 261.0~263.0℃
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White or Off-White Crystalline Powder
Odor Characteristic
Solubility Sparingly Soluble in Methylene Chloride, Slightly Souble in Methanol, Parctically Insoluble in Water, Disolves in 1M Solution Hydroxide
IR Identification Should Correspond to the RS Infrared Absorption
HPLC Identification Retention Time of Major Peak Should Correspond to RS
Purity / Analysis Method >99.5% (HPLC)  
Loss on Drying <1.00%
Residue on Ignition <0.10%
Related Substances  
Telmisartan Related Compound A <0.10%
Telmisartan Amide <0.10%
Telmisartan Related Compound B <0.10%
Telmisartan Diacide <0.10%
Telmisartan Tert-Butyl Ester <0.20%
Telmisartan Unknown Impurity <0.20%
Unspecified Impurity <0.10%
Total Impurities <1.00%
Residual Solvents  
Methanol <0.30%
Ethanol  <0.50%
Methylene Dichloride <0.06%
n-Hexane <0.029%
Acetic Acid Ethyl Ester <0.50%
Toluene <0.089%
Acetic Acid <0.50%
Heavy Metals <10ppm
Arsenic (As) <1.00ppm
Lead (Pb) <1.00ppm
Cadmium (Cd) <1.00ppm
Particle Size D90 Not More Than 15μm
Bulk Density (g/cc) 0.11~0.20
Tapped Density (g/cc) 0.22~0.30
Residual Pesticide Negative
Total Plate Count  <1000cfu/g
Yeast & Mold <100cfu/g
E. Coli Negative
Salmonella Negative
Test Standard Enterprise Standard; USP 41 Standard
Usage API

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

1

FAQ:

Application:

Telmisartan (CAS: 144701-48-4) is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. Telmisartan is a new type of blood pressure drugs, is used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Telmisartan was originally formulated by the German pharmaceutical company Boehringer Ingelheim; it earned the German patent EP502,314 in 1991, was first approved to enter the American market in November 1998, and then entered German, Philippines, Australian, Belgium, British, and other markets.

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