(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS 85977-52-2 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate Factory

Short Description:

(S)-1,2,3,4-1-Tetrahydro-Naphthoic Acid

CAS: 85977-52-2

Appearance: White or Almost White Crystalline Powder

Purity: ≥99.0% e.e≥99.0% 

Intermediate of Palonosetron Hydrochloride (CAS: 135729-62-3) in the treatment of CINV

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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85977-52-2 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality, intermediate of Palonosetron Hydrochloride (CAS: 135729-62-3). Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years. Ruifu Chemical can provide competitive price, excellent service. Purchase please contact us by e-mail: alvin@ruifuchem.com  

Intermediates of Palonosetron Hydrochloride:

85977-52-2 - Chemical Properties:

Chemical Name (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid
Synonyms (1S)-1,2,3,4-Tetrahydronaphthalene-1-Carboxylic acid
CAS Number 85977-52-2
Stock Status In Stock, Commercial Production  
Molecular Formula C11H12O2
Molecular Weight 176.21
Density 1.186±0.06 g/cm3  
Melting Point 54.0~56.0℃ 
Boiling Point 342.7°C at 760 mmHg
Refractive Index 1.576
COA & MSDS Available
Origin of Product    Shanghai, China
Product Categories Pharmaceutical Intermediates
Brand Ruifu Chemical

85977-52-2 - Specifications:

Item Specifications
Appearance White or Almost White Crystalline Powder
Chemical Purity ≥99.0%
Enantimoer Excess e.e. ≥99.0%
Isomer Impurity ≤1.0%
Loss on Drying ≤0.50%
Relate Substance ≤1.0%
Moisture (K.F) ≤1.0%
Specific Rotation [α]D20 -59.0°~ -63.0°(C=0.3 in Benzence)
Heavy Metals ≤20ppm
Storage 5-8℃ Airtightness
Test Standard Enterprise Standard
Usage Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates 

85977-52-2 - Route of Synthesis:

(S)-1,2,3,4-tetrahydro-1-Naphthoic Acid CAS: 85977-52-2 Route of Synthesis 

85977-52-2

85977-52-2 - Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

85977-52-2 - Advantages:

1

85977-52-2 - FAQ:

Factory Shanghai Ruifu Chemical Co., Ltd. www.ruifuchem.com

85977-52-2 - Risk and Safety:

Risk Codes R22 - Harmful if swallowed
R36 - Irritating to the eyes
R51 - Toxic to aquatic organisms
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25 - Avoid contact with skin and eyes.
HS Code 2916399090

85977-52-2 - Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality. It is an intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).

Palonosetron Hydrochloride (CAS: 135729-62-3) is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (~40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. With 1,2,3,4-tetrahydro-1-Naphthoic Acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.  

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