Posaconazole Intermediate POA CAS 149809-43-8 Factory High Quality

Short Description:

Name: Posaconazole Intermediate POA

CAS: 149809-43-8

Appearance: White to Grey White Powder

Purity: ≥99.0%  

Intermediate of Posaconazole (CAS 171228-49-2) Triazole Antifungal Agent

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Chemical Properties:

Name Posaconazole Intermediate POA 
Synonyms (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester; (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate 
CAS Number 149809-43-8
CAT Number RF-PI291
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C21H21F2N3O4S
Molecular Weight 449.47
Density 1.40
Shipping Condition Shipped Under Ambient Temperature
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Grey White Powder
Identification  IR In accordance with the standard
Melting Point 100.0-102.0℃
Specific Rotation [a]20/D -40.0° to -48° (C=1, CHCl3)
Loss on Drying ≤0.50%
Residue on Ignition ≤0.20% 
Heavy Metals ≤20ppm
Related Substances  
Major Impurity ≤0.40% 
POA-Enantiomer ≤0.10%
POA-Diastereomer ≤0.20%
Individual Unknown Impurity ≤0.20%
Total Impurities ≤1.0%
Purity ≥99.0% 
Assay   98.0%~102.0% (anhydrous substance)
Test Standard Enterprise Standard
Usage Intermediate of Posaconazole (CAS 171228-49-2)

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester (CAS 149809-43-8) is the Intermediate of Posaconazole (CAS 171228-49-2). Posaconazole is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.

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