3,3′,5-Triiodo-L-Thyronine (Liothyronine; T3) CAS 6893-02-3 Purity >95.0% (HPLC) Factory

3,3',5-Triiodo-L-Thyronine (Liothyronine; T3) (CAS: 6893-02-3) is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively. Liothyronine is a hormone secreted by the thyroid. It is formed by the condensation of L-3-Monoiodotyrosine and L-3.5-Diiodotyrosine. The content in thyroid tissue and blood is far less than that of thyroxine, but its biological activity is 5 to 10 times higher than it. T3 has the effect of promoting material metabolism and energy release; it can also promote growth and development. The normal adult thyroid secretes 30 μg T3 per day, 20% of T3 in plasma comes from the direct secretion of the thyroid, and 80% comes from the transformation of plasma T4 in the periphery. Levothyroxine or L-Thyroxine is a synthetic thyroid hormonethat is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treatthyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia(elevated cholesterol levels) but was withdrawn due to cardiac side effects. Liothyronine is traditionally utilize during cutting, dieting, and/or pre-contest phases of training due to the universal goal of these phases to break down body fat, though in recent years T3 has gained some popularity as a useful agent during bulking and mass gaining phases of training (normally in conjunction with steroids) in order to better efficiently process nutrients and/or to keep body fat levels down during periods of higher caloric intake. Liothyronine is commonly used with steroids due to its significant impact on the body's metabolism as a whole. It is very important to understand that T3 is indiscriminate in its metabolism boosting properties - it will increase the metabolism of fats, carbohydrates, and protein all equally. Therefore, beyond a particular dose of T3, there is an increased risk of muscle loss through increased turnover of protein. Through the use of steroids and a properly adjusted diet, this muscle loss as a result of T3 can be prevented as a result of the nitrogen-retaining and protein sparing properties of the steroids. Liothyronine is also commonly combined with other fat loss agents in order to increase its overall effect, as it does work synergistically with other fat loss agents.