Fmoc-Ser(HPO3Bzl)-OH CAS 158171-14-3 Fmoc-O-(Benzylphospho)-L-Serine Purity >98.0% (HPLC)

Short Description:

Fmoc-O-(Benzylphospho)-L-Serine 

Synonyms: Fmoc-Ser(HPO3Bzl)-OH

CAS: 158171-14-3

Purity: >98.0% (HPLC)

Appearance: White to Off-White Powder

Fmoc-Amino Acids, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Fmoc-O-(Benzylphospho)-L-Serine (Fmoc-Ser(HPO3Bzl)-OH) (CAS: 158171-14-3) with high quality. Ruifu Chemical supplys a series of amino acids. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Fmoc-Ser(HPO3Bzl)-OH, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Fmoc-O-(Benzylphospho)-L-Serine 
Synonyms Fmoc-Ser(HPO3Bzl)-OH; Fmoc-L-Ser(HPO3Bzl)-OH; Fmoc-Ser(PO(OBzl)OH)-OH; Fmoc-L-Ser(PO(OBzl)OH)-OH; Fmoc-O-(Benzylphospho)-L-Serine; Fmoc-O-Benzylphospho-L-Serine; Fmoc-O-Benzyl-L-Phosphoserine; O-Benzylphospho-N-Fmoc-L-Serine; N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-Benzyl-L-Phosphoserine
Stock Status In Stock 
CAS Number 158171-14-3
Molecular Formula C25H24NO8P
Molecular Weight 497.43  
Density 1.403±0.06 g/cm3 
Water Solubility  Slightly Soluble in Water 
Storage Temp.  Cool & Dry Place (2~8℃) 
COA & MSDS Available
Category   Fmoc-Amino Acids 
Brand Ruifu Chemical

Safety Information:

WGK Germany 3                            HS Code           2922491990                        
10-21

Specifications:

Items Inspection Standards Results
Appearance White to Off-White Powder  White Powder
Specific Rotation [α]20/D -12.0° to -14.0° (C=1, DMF)
-13.1°
TLC ≥98.0% >98.0%
Element Analysis (C、H、N) ≤5.0% <5.0%
Loss on Drying <0.50% 0.23% 
Clarity of Solution 0.3 gram in 2ml DMF Clear Solution Complies
AcOH  <0.50% (HPLC) 0.101%
Purity / Analysis Method >98.0% (HPLC)  98.68% 
Infrared Spectrum Conforms to Structure Complies      
Proton NMR Spectrum Conforms to Structure Complies      
Conclusion The product has been tested & complies with the specifications

Package & Storage:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

Application:

Fmoc-O-(Benzylphospho)-L-Serine (Fmoc-Ser(HPO3Bzl)-OH) (CAS: 158171-14-3) is a serine derivative, building block for the synthesis of phosphoserine containing peptides, phospho amino acids for phosphopeptides.
Fmoc-Ser(HPO3Bzl)-OH can be applied in the synthesis of phosphopeptides. This derivative can be introduced using standard activation methods, such as PyBOP and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. β-piperidinylalanine formation has been shown to occur during Fmoc deprotection of N-terminal Ser(PO(OBzl)OH), particularly under microwave conditions. This side reaction can be eliminated by using cyclohexylamine or DBU just for this Fmoc deprotection step.
Fmoc-Ser(HPO3Bzl)-OH is a monobenzyl protected phospho amino acid that significantly improved the synthesis of phosphorpeptides with higher yields and purities. Phosphopeptides are widely employed in cell signaling and also can work as self antigens which may induce positive immune responses.  

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