Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS 86728-85-0 Atorvastatin Calcium Intermediate

Short Description:

Chemical Name: Ethyl (S)-4-Chloro-3-hydroxybutyrate

CAS: 86728-85-0

Appearance: Colorless to Pale Yellow Liquid

Purity: ≥98.0% (GC)  

Intermediate of Atorvastatin Calcium (CAS: 134523-03-8)  

Inquiry: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Description:

10

Chemical Properties:

Chemical Name Ethyl (S)-4-Chloro-3-hydroxybutyrate
Synonyms (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester
CAS Number 86728-85-0
CAT Number RF-PI139
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C6H11ClO3
Molecular Weight 166.6
Density  1.19 g/mL at 25℃ (lit.)
Refractive Index  n20/D 1.453 (lit.)
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance Colorless to Pale Yellow Liquid
Purity / Analysis Method ≥98.0% (GC) 
Moisture (K.F) ≤0.50%
Ethyl-4-Chloro Aceto Acetate ≤0.50%
Test Standard Enterprise Standard
Usage Pharmaceutical Intermediate; Organic Synthesis

Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0)
Method of analysis
Description
Take about 10ml sample in a clean and dry glass plate and check.
Specific rotation
Transfer accurately about 1.0g of sample to 100ml volumetric flask and dissolved in 10 ml of chloroform, then dilute with chloroform to 100ml and mix.
Measure the optical rotation of the test sample at 25ºC and 589nm wavelength calculate the specific rotation as per the given formula.
[α]25D = (v×a)/[w×(1-b)]
[α]25D: the specific rotation of test sample; α: the observed rotation in angular degree; w: sample weight (g);
v: volume (mL);
b: Water content(%)
Purity (by GC)
Chromatographic conditions: The Gas chromatography is equipped with flame ionization detector
Column: SE-54, 30m×0.35mm×0.25µm
Oven temperature: Initial temp 120℃, Hold time for 2min
Ramp: 20℃/min
Temp: 250℃, Hold time for 2min
Injector temperature: 250℃
Detector temperature: 250℃(FID)
Injection volume: 0.2µl
Sample solution: dilute 1ml A4 with 1ml acetone.
Procedure: Inject 0.2µl of the acetone as blank and record the chromatogram. In the chromatogram obtained from diluent there should not be any interference at the retention time of the main peak and impurity peak. Than Inject the sample solution in duplicate into the chromatograph and record the chromatogram. Report the Purity of sample by area normalization method.

Package & Storage:

Package: Bottle, Barrel, 25kg/Barrel, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

2

Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0) with high quality, it is an intermediate typically in the synthesis of Atorvastatin Calcium (CAS: 134523-03-8).   

Atorvastatin Calcium (CAS: 134523-03-8) [trade name: Lipitor]  is mainly indicated for the treatment of cardiovascular disease and dyslipidemia due to its effect in lowering the cholesterol in the blood. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels further increases hepatic uptake of cholesterol and reduces plasma cholesterol levels. Lipitor, since 1996, has become the world's best-selling medication to that point. 

  • Write your message here and send it to us