CAS 945667-22-1 Purity >99.0% (HPLC) API

Short Description:

CAS: 945667-22-1

Purity: >99.0% (HPLC) 

Appearance: White Powder 

API, High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Description:

Chemical Properties:

Synonyms BMS-477118 Hydrate; Onglyza Hydrate; (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate; (1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate
CAS Number 945667-22-1
CAT Number RF-PI1992
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C18H25N3O2·H2O      
Molecular Weight 333.43
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White Powder
identification A: IR  B: HPLC Retention Time
Purity / Analysis Method >99.0% (HPLC, On Dried Basis)
Water Content (K.F) 5.3%~7.3%
Residue on Ignition <0.20%
Single Impurity <0.50%
Total Impurities <1.00%
Heavy Metals <10ppm
Arsenic (As) <2ppm
Microbiology  
Total Plate Count <1000cfu/g
Yeast & Mold <100cfu/g
E. Coli Negative 
S. Aureus Negative 
Salmonella Negative 
Shelf Life 24 Months
Test Standard Enterprise Standard
Usage API; Used for the Treatment of Type II Diabetes

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

1

FAQ:

Application:

API (CAS: 945667-22-1) is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes. It is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.IC50 value: 26 nM. Target: DPP4 in vitro: It has an inhibition constant Ki of 1.3 nM for DPP4 inhibition, which is 10-fold more potent than Sitagliptin (another two DPP4 inhibitors) with Ki of 13 and 18 nM. In addition, It demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes (400- and 75- fold, respectively). The active metablite of it is two-fold less potent than the parent. Both (CAS: 945667-22-1) and its metabolite are highly selective (>4000-fold) for the prevention of DPP4 compared with a range of other proteases. (CAS: 945667-22-1) reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion.in vivo: It is highly effective at eliciting marked dose-dependent enhancements in glucose clearance in the dose range 0.13-1.3 mg/kg in ob/ob mice relative to controls.

  • Write your message here and send it to us