Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) e.e ≥99.0%

Short Description:

Chemical Name: (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine 

CAS: 877399-00-3

Purity: ≥98.0% (HPLC) e.e ≥99.0%

Appearance: Light Yellow to Yellow Powder to Crystal

Intermediate of Crizotinib (CAS: 877399-52-5) 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401


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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) with high quality, intermediate of Crizotinib (CAS: 877399-52-5). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Crizotinib Intermediate, Please contact:

Crizotinib Intermediates:

Chemical Properties:

Chemical Name (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine 
Synonyms Crizotinib Intermediate; Crizotinib Bromide Impurity; 5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-2-Pyridinamine; [5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine
Stock Status In Stock, Commercial Production     
CAS Number 877399-00-3 
Molecular Formula C13H10BrCl2FN2O
Molecular Weight 380.04 g/mol
Melting Point 108.0 to 113.0℃ 
Density 1.643 
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Category   Intermediate of Crizotinib (CAS: 877399-52-5) 
Brand Ruifu Chemical


Items Inspection Standards Results
Appearance Light Yellow To Yellow Powder to Crystal Complies      
Melting Point 108.0 to 113.0℃ Complies      
Purity (HPLC Area) ≥98.0%   99.1%
Enantiomeric Excess (E.E) ≥99.0%  99.5%
Infrared Spectrum Conforms to Structure Complies      
1 H NMR Spectrum Conforms to Structure Complies      
Conclusion This product has been tested & complies with the specifications
Shelf Life 2 Years if Stored Properly 


Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 


Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system


How to Purchase? Please contact Dr. Alvin Huang: or 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 


(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) is used as an intermediate of Crizotinib (CAS: 877399-52-5). 

Crizotinib is definitely an anti-cancer drug becoming an alk (anaplastic lymphoma kinase) and ros1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the usa and some other countries, and undergoing numerous studies testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in adults and children.    

Crizotinib is a targeted therapy drug for non-small cell lung cancer developed by Pfizer, USA, secorri is a frontier and epoch-making drug in the field of targeted therapy for lung cancer. It was approved for marketing in the United States in August 2011 and was written into international lung cancer treatment guidelines at the end of the year as a first-line drug for ALK-positive patients. Co-approved with Crizotinib is the first genetic diagnosis method using fluorescence in situ hybridization (FISH)-VSIs ALK Break Apart FISH Probe Kit, this is the method currently used in global clinical trials to detect EML4-ALK fusion genes in NSCLC. This test will help identify patients who may benefit from Crizotinib treatment.  

Crizotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of selected cases of advanced non-small cell lung cancer. It is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When Crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, Crizotinib was found to inhibit RON (recepteur d’origine nantais) kinase with a 10-fold selectivity window over c-MET. Altogether, this agent inhibits tumor cell growth. XALKORI®(Crizotinib) is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children. 

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