N-Ethyl-N-Methylcarbamoyl Chloride CAS 42252-34-6 Rivastigmine Tartrate Intermediate Purity >99.0% (GC)

Short Description:

Chemical Name: N-Ethyl-N-Methylcarbamoyl Chloride

Synonyms: Ethyl(methyl)carbamic Chloride 

CAS: 42252-34-6

Purity: >99.0% (GC)

Appearance: Colorless Liquid

Intermediate of Rivastigmine Tartrate (CAS: 129101-54-8)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N-Ethyl-N-Methylcarbamoyl Chloride (Ethyl(methyl)carbamic Chloride) (CAS: 42252-34-6) with high quality, intermediate of Rivastigmine Tartrate (CAS: 129101-54-8). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase N-Ethyl-N-Methylcarbamoyl Chloride, Please contact: alvin@ruifuchem.com

Rivastigmine Tartrate Intermediates:

Chemical Properties:

Chemical Name N-Ethyl-N-Methylcarbamoyl Chloride 
Synonyms Ethyl(methyl)carbamic Chloride; Rivastigmine Intermediate 1
Stock Status In Stock, Commercial Production  
CAS Number 42252-34-6
Molecular Formula C4H8ClNO 
Molecular Weight 121.56 g/mol
Boiling Point 89℃/40mmHg(lit.)  
Density 1.101±0.06 g/cm3 
Refractive Index n20/D 1.4500~1.4540
Sensitive Moisture Sensitive
COA & MSDS Available
Sample  Available
Origin Shanghai, China
Category   Intermediate of Rivastigmine Tartrate (CAS: 129101-54-8) 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance Colorless Liquid  Colorless Liquid  
Purity / Analysis Method >99.0% (GC)  99.15%
Related Substance (GC)
Single impurity <0.50% Complies 
Total Impurities <1.00% 0.85%
Infrared Spectrum Consistent with Structure Complies 
1H NMR Spectrum Consistent with Structure Complies
Conclusion The product has been tested and complies with the given specifications

Package/Storage/Shipping:

Package: Fluorinated Bottle, 25kg/Drum, 180kg/Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory AuditFactory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
TransportationBy Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom SynthesisCan provide custom synthesis services to best fit your research needs.
Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

63-91-2 - Safety Information:

RIDADR 3265
HazardClass 8
PackingGroup II
HS Code 2924199090

Application:

N-Ethyl-N-Methylcarbamoyl Chloride (Ethyl(methyl)carbamic Chloride) (CAS: 42252-34-6), intermediate of Rivastigmine Tartrate (CAS: 129101-54-8). Rivastigmine Tartrate is the tartrate of rivastigmine, a drug for the treatment of Alzheimer's disease. Rivastigmine is a physostigmine derivative, which was successfully developed for the first time by Novartis, Switzerland. The trade name is exelon, and the molecule has a benzyl carbamate structure, it is a carbamate brain-selective cholinesterase inhibitor, which can inhibit acetylcholinesterase and butyrylcholinesterase at the same time, and promote cholinergic nerve conduction by delaying the degradation of acetylcholine released by cholinergic neurons. It can improve the cognitive dysfunction mediated by cholinergic, thereby improving the cognitive effect of patients with Alzheimer's disease. The plasma protein binding capacity of rivastigmine is weak, easy to pass through the blood-brain barrier, and has a high degree of brain selectivity. It can not only selectively act on the most vulnerable areas of the cerebral cortex and hippocampus, but also preferentially inhibit the dominant subtypes of AChE in the brain, which can reduce peripheral cholinergic side effects while producing curative effects. The half-life of rivastigmine tartrate in the body is short and the action time is long. Unlike tacrine, this product has a stronger inhibitory effect on G1 enzyme in the hippocampus and cortex. It is clinically used to treat mild to moderate Alzheimer's dementia, which is suspected of Alzheimer's disease or Alzheimer's disease.

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