(Boc)2NH CAS 51779-32-9 Di-tert-Butyl Iminodicarboxylate Purity >99.0% (HPLC) Factory Protecting Reagent

Short Description:

Chemical Name: Di-tert-Butyl Iminodicarboxylate

Synonyms: (Boc)2NH; N-Boc-tert-Butylcarbamate 

CAS: 51779-32-9

Purity: >99.0% (HPLC)

Appearance: White Crystalline Powder

Protecting Reagents, High Quality 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Di-tert-Butyl Iminodicarboxylate ((Boc)2NH) (CAS: 51779-32-9) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Di-tert-Butyl Iminodicarboxylate, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name Di-tert-Butyl Iminodicarboxylate 
Synonyms (Boc)2NH; tert-Butyl Iminodicarboxylate; N-Boc-tert-Butylcarbamate; Iminodicarboxylic Acid Di-tert-Butyl Ester; Bis(tert-Butoxycarbonyl)ammonia
Stock Status In Stock 
CAS Number 51779-32-9
Molecular Formula C10H19NO4
Molecular Weight 217.27 g/mol
Melting Point 114.0~120.0℃ 
Density 1.037±0.06 g/cm3 
Sensitive Air Sensitive, Light Sensitive 
Water Solubility  Insoluble in Water 
Solubility  Chloroform, Methanol 
Storage Temp.  Cool & Dry Place (2~8℃) 
COA & MSDS Available
Category   Protecting Reagents 
Brand Ruifu Chemical

Specifications:

Items Inspection Standards Results
Appearance White Crystalline Powder  Complies      
Melting Point 114.0~120.0℃ 118.8~119.3℃
Loss on Drying <0.50% 0.10% 
Purity / Analysis Method >99.0% (HPLC)  99.6% 
Infrared Spectrum Conforms to Structure Complies      
NMR Spectrum Conforms to Structure Complies      
Conclusion The product has been tested & complies with the given specifications

Purity Test:

Chromatographic column: SE-54 30m×0.25mm×0.5μm;
Detector: FID
Initial temperature: 100℃
Initial period: 1min
Heating rate: 20℃/min
Final temperature: 190℃
At the end: 10min
Injection temperature: 160℃
Temperature of detector: 200℃
Split ratio: 50:1;
Sample size: 0.2μl;
Diluent: methanol
Result: The purity was greater than 99.0% by area normalization method.

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory AuditFactory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

TransportationBy Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom SynthesisCan provide custom synthesis services to best fit your research needs.

Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

51779-32-9 - Risk and Safety:

Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
HS Code 29241990
Hazard Note Irritant

Application:

Di-tert-Butyl Iminodicarboxylate ((Boc)2NH) (CAS: 51779-32-9)
Application Di-tert-Butyl Iminodicarboxylate is a pharmaceutical intermediate, which can be prepared by one-step reaction of formamide and Boc2O.  
The compound is used as a reagent for the preparation of primary amines from alkyl halides. It was popularized as an alternative to the Gabriel synthesis for the same conversion. Amines can also be prepared from alcohols by dehydration using the Mitsunobu reaction. In the usual implementation the reagent is deprotonated to give the potassium salt, which is N-alkylated. The Boc protecting groups are subsequently removed under acidic conditions.
Di-tert-Butyl Iminodicarboxylate is a protected amine group that is used to prepare conformationally constrained spirocycles as CCR1 antagonists.
Preparation the solution of DMAP (0.61g, 5.0mmol) in MeCN (15ml) is slowly added to the solution of formamide (2.5g,56mmol) and Boc2O (24g, 110mol) in MeCN (15ml). After stirring at room temperature for 4h, the yellow solution was cooled to 0°C, and N,N-diethylenediamine (6.97g, 60mmol) was slowly added at 0℃. The resulting mixture was stirred at room temperature for 12h and filtered through a thin silica pad; the resulting mixture was filtered at room temperature. The solvent is then evaporated under reduced pressure. The crude product was purified by silica gel chromatography and eluted with EtOAc/hexane (1:5) to obtain the title product, which is a white solid (10.99g, 92%). 

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