4-Amino-2-Methylbenzoic Acid CAS 2486-75-1 Tolvaptan Intermediate Factory

Short Description:

Chemical Name: 4-Amino-2-Methylbenzoic Acid 

CAS: 2486-75-1

Purity: ≥99.0% (HPLC)

Appearance: White or Yellowish Crystal Powder 

Intermediate of Tolvaptan (CAS 150683-30-0) for the treatment of Hyponatremia

High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags


Chemical Properties:

Chemical Name 4-Amino-2-Methylbenzoic Acid
Synonyms 4-Amino-o-toluic Acid; Tolvaptan Intermediate N-2
CAS Number 2486-75-1
CAT Number RF-PI394
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C8H9NO2
Molecular Weight 151.17 
Solubility Soluble in Methanol
Brand Ruifu Chemical


Item Specifications
Appearance White or Yellowish Crystal Powder
Purity/Analysis Method ≥99.0% (HPLC)
Moisture ≤0.50% (K.F)
Melting Point 161.0~168.0℃
Residue on Ignition ≤0.50%
Single Impurity ≤0.50%
Total Impurities ≤1.0%
Test Standard Enterprise Standard
Usage Intermediate of Tolvaptan (CAS 150683-30-0), treatment of Hyponatremia

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.





4-Amino-2-Methylbenzoic Acid (CAS 2486-75-1) is used as an intermediate in the synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis. 4-Amino-2-Methylbenzoic Acid is the intermediate of Tolvaptan (CAS 150683-30-0). Tolvaptan is an oral selective vasopressin antagonist developed by Otsuka for the treatment of hyponatremia, and it is a non-peptide selective antidiuretic hormone receptor antagonist. The drug can increase the concentration of sodium ions in the plasma, and help the excess water discharge from the urine. The drug could enhance the ability of the kidney to deal with water, and significantly reduce the weight and edema of patients while not accompanied by increased electrolyte excretion, without destroying the blood electrolyte balance. The drug can be used to treat hyponatremia caused by congestive heart failure, various edematous diseases, cirrhosis and antidiuretic hormone deficiency syndrome.

  • Write your message here and send it to us