3-Nitrophthalic Anhydride CAS 641-70-3 Pomalidomide Intermediate Purity >98.0% (HPLC)

Short Description:

Chemical Name: 3-Nitrophthalic Anhydride 

CAS: 641-70-3

Purity: >98.0% (HPLC)

Light Yellow to Yellow Needle Crystal or Crystalline Powder

Intermediate of Pomalidomide (CAS: 19171-19-8) 

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Description:

Ruifu Chemical is the leading manufacturer of 3-Nitrophthalic Anhydride (CAS: 641-70-3) with high quality, intermediate of Pomalidomide (CAS: 19171-19-8). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase 3-Nitrophthalic Anhydride, Please contact: alvin@ruifuchem.com

Pomalidomide Intermediates:

Chemical Properties:

Chemical Name 3-Nitrophthalic Anhydride 
Synonyms 3-Nitrophthalic Acid Anhydride; 4-Nitro-2-Benzofuran-1,3-Dione; 4-Nitroisobenzofuran-1,3-Dione; 4-Nitro-1,3-isobenzofurandione; Pomalidomide Impurity A
Stock Status In Stock, Commercial Production  
CAS Number 641-70-3 
Molecular Formula C8H3NO5
Molecular Weight 193.11 g/mol
Melting Point 161.0 to 165.0℃ 
Sensitive Moisture Sensitive
Water Solubility  May Decompose in Water   
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

Specifications:

Items Inspection Standards  Results 
Appearance   Light Yellow to Yellow Needle Crystal or Crystalline Powder    Complies      
Melting Point             161.0~165.0℃  163.0~165.0℃ 
Loss on Drying  <0.50%  0.10%  
Purity / Analysis Method  >98.0% (HPLC)   98.85%  
Infrared Spectrum  Consistent with Structure  Complies  
1H NMR Spectrum  Consistent with Structure  Complies  
Conclusion  The product has been tested and complies with the given specifications  
Application  Intermediate of Pomalidomide (CAS: 19171-19-8)  

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Air sensitive. Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire; avoid moisture. Keep away from oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock    

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory AuditFactory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
TransportationBy Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom SynthesisCan provide custom synthesis services to best fit your research needs.
Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

641-70-3 - Safety Information:

Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S37/39 - Wear suitable gloves and eye/face protection
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Yes
HS Code 2917399090

641-70-3 - Application:

3-Nitrophthalic Anhydride (CAS: 641-70-3) is used as an intermediate of Pomalidomide (CAS: 19171-19-8). In February 2013, the US FDA approved Pomalidomide for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC50~10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3-6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 3-Nitrophthalic Anhydride with 3-Aminopiperidine-2,6-Dione followed by catalytic hydrogenation of the nitro group.

  • Write your message here and send it to us