3-Methyl-8-Quinolinesulphonyl Chloride CAS 74863-82-4 Argatroban Intermediate Factory 98.0%

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of 3-Methyl-8-Quinolinesulphonyl Chloride (CAS: 74863-82-4) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis. It is an intermediate typically in the synthesis of Argatroban (CAS: 74863-84-6) or Argatroban Monohydrate (CAS 141396-28-3).

Argatroban (CAS: 74863-84-6) is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy.