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2021 Good Quality Methyl (R)-(+)-2-Chloropropionate - (S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu Featured Image
  • 2021 Good Quality Methyl (R)-(+)-2-Chloropropionate - (S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu

2021 Good Quality Methyl (R)-(+)-2-Chloropropionate - (S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu

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Our organization promises all customers with the first-class products and solutions and the most satisfying post-sale service. We warmly welcome our regular and new clients to join us for Molecular weight 293.31, C10H17NO4, Molecular Formula C20H34BCl, With our rules of " business reputation, partner trust and mutual benefit", welcome all of you to work together , grow together.
2021 Good Quality Methyl (R)-(+)-2-Chloropropionate - (S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu Detail:

Manufacturer with High Quality and Competitive Price
Commercial Supply Palonosetron Hydrochloride and Related Intermediates:
1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 1914-65-4
(S)-1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

Chemical Name (S)-3-Aminoquinuclidine Dihydrochloride
Synonyms (S)-(-)-3-Aminoquinuclidine 2 HCL 
CAS Number 119904-90-4
CAT Number RF-CC112
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C7H16Cl2N2
Molecular Weight 199.12
Solubility in Water Soluble
Brand Ruifu Chemical
Item Specifications
Appearance White to Light Yellow Crystalline Powder 
IR Absorption Spectra Consistent with the Reference
Chloride Reaction Positive Reaction
Purity ≥98.0%
Loss on Drying ≤0.50%
Specific Rotation [α]D20 -22.0°~ -26.0° (C=1, H2O)
Heavy Metals ≤20ppm
Storage 5-8℃ Airtightness
Test Standard Enterprise Standard
Usage Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates 

(S)-3-Aminoquinuclidine Dihydrochloride (CAS: 119904-90-4) Synthetic Route

(S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-3-Aminoquinuclidine dihydrochloride (CAS: 2133-40-6) with high quality. It is a pharmaceutical intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).

Palonosetron Hydrochloride (CAS: 135729-62-3) is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention. With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. 

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2021 Good Quality Methyl (R)-(+)-2-Chloropropionate - (S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Purity ≥99.0% e.e.≥99.0% Palonosetron Hydrochloride Intermediate – Ruifu detail pictures

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